神经干细胞移植治疗脑性瘫痪的疗效观察

2009-12-30 10:36:31

[摘要] 目的探讨神经干细胞（neural stem cells ，NSCs）移植治疗脑性瘫痪的疗效。方法对1 例脑性瘫痪的患者进行静脉及椎管内
NSCs 移植。治疗方案：在30 mins 内将30ml 含108～109 数量的NSCs 注入体内，共4 次，每次间隔3～4d，第1，2，4 次均为静脉注射， 第3
次为5mlNSCs 椎管内注射＋25ml 静脉注射。分别于治疗前及治疗后60d 对患儿进行韦氏儿童智力量表测评， 日常生活活动能力指数
（Barthel index ,BI）及改良Ashworth 痉挛评定量表评定。结果术后60d 患儿肌张力下降，肢体活动能力提高，改良Ashworth 痉挛评定
量表由术前的Ⅱ级降至术后Ⅰ级，BI 由术前的46 分提高至69 分，韦氏儿童智力测验无明显改善。结论NSCs 治疗脑性瘫痪对本例患
儿近期临床效果尚可，远期临床疗效有待进一步观察。
[关键词] 神经干细胞移植脑性瘫痪
[中图分类号] R742.3 [文献标识码] A
Clinical observation of neural stem cell transplantation for cerebral palsy
ZHOU Sheng- nian, HUANG Chao, FU Xiu- xin
(1Department ofNeurology, Qilu Hospital , Shandong University , Jinan 250012, China)
[Abstract] Objective To evaluate the effects of neural stem cell transplantation in treatment of cerebral palsy. Methods To transplant NSCs
to a cerebral palsy patient by vein or vertebral canal. Treatment prescription: The operator injected 108－109 neural stem cells 30ml to the patient by
vein or vertebral canal in 30 mins every fourth or fifth day , four times in all. The first 、second and fourth time were intravenous injection, the fourth
time was intravenous injection with 25ml and intrathecal injection with 5ml. Before treatment and 60 days later , we both evaluated the state of the
patient with Wechsler intelligence scale、Barthel index (BI) and modified Asthworth criteria . Results the intelligence quotient didn't improve, the
muscular tension was reduce to gradeⅠ from grade Ⅱ, and the BI rose to 69 marks from 46 marks . Conclusion The short- term clinical effects
of NSCs for this patient with cerebral palsy was acceptable , and Many more studies are needed to evaluate long- term effects of NSCs in treatment of
cerebral palsy.
[Key words] Neural stemcell ; Transplantation; Cerebral palsy